Mast-Cell-Derived TNF Amplifies CD8+ Dendritic Cell Functionality and CD8+ T Cell Priming
Mast cells are critical promoters of adaptive immunity Seasonal Decorations in the contact hypersensitivity model, but the mechanism of allergen sensitization is poorly understood.Using Mcpt5-CreTNFFL/FL mice, we show here that the absence of TNF exclusively in mast cells impaired the expansion of CD8+ T cells upon sensitization and the T-cell-driv